Protein Details: Gamma-aminobutyric acid receptor subunit beta-like

Protein ID

ICDB_Pro_0783

Protein Name

Gamma-aminobutyric acid receptor subunit beta-like

Gene Name

Lcch3; CG17336

Organism

Drosophila melanogaster (Fruit fly)

Length

496 amino acids

AlphaFoldDB

AF-Q08832-F1-model_v4.pdb

Function

GABA; an inhibitory neurotransmitter; mediates neuronal inhibition by binding to the GABA receptor and opening an integral chloride channel. Combines with the ligand-gated ion channel subunit GRD to form cation-selective GABA-gated ion channels when coexpressed in Xenopus laevis oocytes.

Sequence

MTCFTRVGVSCGLFFFLLGAQLQLIRCIRKDVLAGRLENVTQTISNILQGYDIRLRPNFGGEPLHVGMDLTIASFDAISEVNMDYTITMYLNQYWRDERLAFNIFGQYFDDENDDGISDVLTLSGDFAEKIWVPDTFFANDKNSFLHDVTERNKLVRLGGDGAVTYGMRFTTTLACMMDLHYYPLDSQNCTVEIESYGYTVSDVVMYWKPTPVRGVEDAELPQFTIIGYETNDRKERLATGVYQRLSLSFKLQRNIGYFVFQTYLPSILIVMLSWVSFWINHEATSARVALGITTVLTMTTISTGVRSSLPRISYVKAIDIYLVMCFVFVFAALLEYAAVNYTYWGKRAKKKIKKVKECCPGKIGKSERSETCSTTEDIIELQDVRMSPIPSLRRGTYNATLDSIGTETMNLGKFPPSFRITRNYGTGHSQLRRRAQRGISTRPRMLHALKRGASAIKATIPKIKDVNIIDKYSRMIFPISFLAFNLGYWLFYILE

PDB Structures

Ligand Binding

1. DICL_CP

2. DICL_Pep

Binding Site

Disease

Location

DOI ID

10.1006/bbrc.1993.1648; 10.1126/science.287.5461.2185; 10.1186/gb-2002-3-12-research0083; 10.1186/gb-2002-3-12-research0080; 10.1016/0965-1748(94)90029-9; 10.1038/sj.bjp.0705818

RefSeq

NP_996469.1